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Cryptococcosis and histoplasmosis are systemic fungal infections caused by the organisms Cryptococcus neoformans and Histoplasma capsulatum. Cases of infection are worldwide and sporadic. These organisms are found in soil, pigeons, and starlings and are spread in bird feces. These systemic fungi have a predilection for the lung and central nervous system. There is an increased susceptibility in humans on steroid therapy and with disorders of the reticuloendothelial system.